刘润辉 - 杏悦2

刘润辉

发布时间💇🏿‍♀️：2019-12-09 访问次数:141164 作者:网站管理员

刘润辉 教授、博导、获国家杰出青年科学基金

上海市青年学术带头人、东方学者🏵、霍尼韦尔学者

研究方向（多领域交叉研究）👩‍⚖️：模拟多肽的高分子生物材料、生物医药、高端医疗器械👩‍🦯、生物传感领域交叉研究

方向1：高分子合成、水凝胶🎶、高分子生物材料、骨软骨血管等组织修复、抗菌材料🙇🏼、药物及mRNA递送🏊🏼‍♀️、干细胞培养载体🧨🚨、干细胞体内治疗

方向2：多肽合成、抗耐药细菌和真菌多肽👩🏼‍🚀、抗肿瘤药物发现和修饰🤳🏻、糖尿病药物发现和修饰、糖尿病药物长效释放

方向3：智能传感（集成电路材料）、脑机接口、生物检测芯片👨🏻‍🦼‍➡️、人工智能（用于生物材料和生物医药的设计和发现）、计算模拟

Email： rliu@ecust.edu.cn Tel: 021-64253402

办公室🛏🌾：徐汇校区科辅二楼二层C203

邮政地址：上海市梅陇路130号546信箱

招生专业🕹：材料科学与工程

本课题组常年招收博士后；招收博士🤽、硕士研究生

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教育及研究经历⏩：

2004-2009 美国普渡大学(Purdue University) 博士

2009-2010 美国加州理工杏悦2(California Institute of Technology) 博士后

2010-2014 美国威斯康星大学麦迪逊校区(University of Wisconsin-Madison) 博士后

代表性学术论文:

42. Wu, Y.*; Chen, K.; Wang, J.; Dai, W.; Yu, H.; Xie, X.; Chen, M.; Liu, R.*, Open-vessel Polymerization of N-carboxyanhydride (NCA) for Polypeptide Synthesis Nat. Protocol, 2024, DOI:10.1038/s41596-024-01062-3.

41. Wu, Y.*; Chen, K.; Wang, J.; Chen, M.; Dai, W.; Liu, R.*, Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization. J. Am. Chem. Soc., 2024, 146, 24189–24208

40. Zhou, M.#;Liu, L.#; Cong, Z.; Jang, W.; Xiao X.; Xie J.; Luo, Z.; Chen, S.; Wu, Y.; Xue, X.; Shao, N.; Liu, R.* Membrane and DNA Dual-Targeting Strategy to Combat Multidrug-Resistant Fungi and Mitigate Antifungal Resistance, Nature Microbiology, 2024, 9,1325-1339.

39. Shao, N.; Yuan, L.; Liu, L.; Cong, Z.; Wang, J.; Wu, Y.; Liu, R.* Reversing Anticancer Drug Resistance by Synergistic Combination of Chemotherapeutics and Membranolytic Antitumor β-Peptide Polymer. J. Am. Chem. Soc. 2024, 146(16), 11254-11265.

38. Jiang, W.; Zhou, M.; Chen, S.; Xie, J.; Chen, M.; Zhang, H.; Wu, Y.; Chen, X.; Liu, R.* Peptide-mimicking poly(2-oxazoline)s possessing potent antifungal activity and BBB penetrating property to treat invasive infections and meningitis. J. Am. Chem. Soc. 2023, 145, 47, 25753–25765.

37. Chen, Q.; Zhang, X.; Zhang, D.; Liu, G.; Ma, K.; Liu, J.; Ma, K.; Chen, M.; Li, Y.; Liu, R.*Universal and one-step modification to render diverse materials bioactivation. J. Am. Chem. Soc. 2023, 145, 18084.

36. Wu, Y.; Chen, K.; Wang, J.; Chen, M.; Chen, Y.; She, Y.; Yan, Z.; Liu, R.* Host defense peptide mimicking antimicrobial amino acid polymers and beyond: design, synthesis and biomedical applications. Prog. Polym. Sci. 2023, 141, 101679.

35. Zhang, H.^#; Chen, Q.^#; Xie, J.^#; Cong, Z.; Cao, C.; Zhang, W.; Zhang, D.; Chen, S.; Gu, J.; Deng, S.; Qiao, Z.; Zhang, X.; Li, M.; Lu, Z.; Liu, R.* Switching from membrane disrupting to membrane crossing, an effective strategy in designing antibacterial polypeptide. Sci. Adv. 2023, 9(4), eabn0771.

34. Zhou, R.; Wu, Y.; Chen, K.; Zhang, D.; Chen, Q.; Zhang, D.; She, Y.; Zhang, W.; Liu, L.; Zhu, Y.; Gao, C.; Liu, R.* A Polymeric Strategy Empowering Vascular Cell Selectivity and Potential Application Superior to Extracellular Matrix Peptides. Adv. Mater. 2022, 34(42), e2200464.

33. Xiao, X.^#; Zhou, M.^#; Cong, Z.; Liu, L.; Zou, J.; Ji, Z.; Cui, R.; Wu, Y.; Zhang, H.; Chen, S.; Li, M.; Liu, R.* Controllable Polymerization of N-Substituted β-Alanine N-Thiocarboxyanhydrides for Convenient Synthesis of Functional Poly(β-peptoid)s. CCS Chemistry 2023, 5(4), 994-1004.

32. Wu, Y.^#; Jiang, W.^#; Cong, Z.; Chen, K.; She, Y.; Zhong, C.; Zhang, W.; Chen, M.; Zhou, M.; Shao, N.; Xiao, G.; Shao, X.; Dai, Y.; Fei, J.; Song, G.; Liu, R.* An Effective Strategy to Develop Potent and Selective Antifungal Agents from Cell Penetrating Peptides in Tackling Drug-Resistant Invasive Fungal Infections. J. Med. Chem. 2022, 65 (10), 7296–7311.

31. Zhang, W.; Wu, Y.; Chen, Q.; Zhang, H.; Zhou, M.; Chen, K.; Cao, C.; Guo, H.; Xu, J.; Liu, H.; Lin, H.; Liu, C.; Liu, R.*Statistic Copolymers Working as Growth Factor-Binding Mimics of Fibronectin. Adv. Sci. 2022, 9(21), 2200775.

30. Shao, N.; Yuan, L.; Ma, P.; Zhou, M.; Xiao, X.; Cong, Z.; Wu, Y.; Xiao, G.; Fei, J.; Liu, R.* Heterochiral β-Peptide Polymers Combating Multidrug-Resistant Cancers Effectively without Inducing Drug Resistance. J. Am. Chem. Soc. 2022, 144 (16), 7283-7294.

29. Zhang, D.; Shi, C; Cong, Z; Chen, Q; Bi, Y; Zhang, J; Ma, K; Liu, S; Gu. J; Chen, M; Lu, Z; Zhang, H; Xie, J; Xiao, X; Liu, L; Jiang, W; Shao, N; Chen, S; Zhou, M; Shao, X; Dai, Y; Li, M; Zhang, L; Liu, R.* Microbial Metabolite Inspired β-Peptide Polymers Displaying Potent and Selective Antifungal Activity. Adv. Sci. 2022, 2104871.

28. Jiang, W.^#; Zhou, M.^#; Cong, Z.; Xie, J.; Zhang, W.; Chen, S.; Zou, J.; Ji, Z.; Shao, N.; Chen, X.; Li, M.; Liu, R.* Short Guanidinium-Functionalized Poly(2-oxazoline)s Displaying Potent Therapeutic Efficacy on Drug-Resistant Fungal Infections. Angew. Chem. Int. Ed. 2022, 61(17), e202200778

27. Wu, Y. ^#; Lin, Y. ^#; Cong, Z.; Chen, K.; Xiao, X.; Wu, X.; Liu, L.; She, Y.; Liu, S.; Zhou, R.; Yin, G.; Shao, X.; Dai, Y.; Lin, H.*; Liu R.* Peptide Polymer-Doped Cement Acting as an Effective Treatment of MRSA-Infected Chronic Osteomyelitis. Adv. Funct. Mater.2022, 32(7), 2107942.

26. Qian Y., Deng, S.,Cong Z., Zhang, H., Lu Z., Shao N., Bhatti S.A., Zhou C., Cheng J., GellmanS.H.*, and Liu R.* Secondary Amine Pendant β-peptide Polymers DisplayingPotent Antibacterial Activity and Promising Therapeutic Potential in TreatingMRSA-Induced Wound Infections and Keratitis. J. Am. Chem. Soc., 2022, 144(4), 1690–1699.

25. Zhang, D.#; Liu, J.#; Chen, Q.; Jiang, W.; Wang, Y.; Xie, J.; Ma, K.; Shi, C.; Zhang, H.; Chen, M.; Wan, J.; Ma, P.; Zou, J.; Zhang, W.; Zhou, F.; Liu, R.* A Sandcastle Worm-Inspired Strategy to Functionalize Wet Hydrogels. Nature Communications 2021, 12, 6331.

24. Wu, Y.; Chen, K.; Wu, X.; Liu, L.; Zhang, W.; Ding, Y.; Liu, S.; Zhou, M.; Shao, N.; Ji, Z.; Chen, J.; Zhu, M.; Liu, R.* Superfast and Water-Insensitive Polymerization on α-Amino Acid N-Carboxyanhydrides to Prepare Polypeptides using Tetraalkylammonium carboxylates as the Initiator. Angew. Chem. Int. Ed. 2021. 60, 26063-26071.

23. Xie, J.#; Zhou, M.#; Qian, Y.; Cong, Z.; Chen, S.; Zhang, W.; Jiang, W.;Dai, C.; Shao, N.; Ji, Z.; Zou, J.; Xiao, X.; Liu, L.; Chen, M.; Li, J.;Liu, R.* Addressing MRSA Infection andAntibacterial Resistance with Peptoid Polymers. Nature Communications 2021, 12, 5898.

‍(Highlighted by BioCentury Innovations)

22. Zhang, D.; Chen, Q.; Bi, Y.; Zhang, H.; Chen, M.; Wan, J.; Shi, C.; Zhang, W.; Zhang, J.; Qiao, Z.; Li, J.; Liu, Y.; Chen, S.; Liu, R.* Bio-Inspired Hydrogels Resist the Foreign-Body Response. Nature Communications 2021, 12, 5327.

(Highlighted by Etracellular Matrix News as TOP STORY)

21. Zhou, M.; Zou, J.; Liu, L.; Xiao,X.; Deng, S.; Wu, Y.; Xie, Jia.; Cong, Z.; Ji, Z.; Liu, R.*Synthesis of Poly-α/β-peptideswith Tunable Sequence Via the Copolymerization on N-carboxyanhydride and N-thiocarboxyanhydride. iScience, 2021, 24(10): 103124.

20. Chen, Q.; Zhang D.; ZhangW.; Zhang H.; Zou J.; ChenM.; LiJ.; Yuan Y.; Liu, R.*Dual mechanismβ-amino acid polymers promoting cell adhesion. Nature Communications 2021, 12, 562

19. Zhang, D.; Chen, Q.; Shi, C.; Chen, M.; Ma, K.; Wan, J.; Liu, R.* Dealing with the Foreign-Body Response to Implanted Biomaterials: Strategies and Applications of New Materials. Adv. Funct. Mater. 2021, 31, 2007226.

18. Etayash, H.; Qian, Y.; Pletzer, D.; Zhang, Q.; Xie, J.; Cui, R.; Dai, C.; Ma, P.; Qi, F.; Liu, R.* Hancock, R. E. W.* Host Defense Peptide-Mimicking Amphiphilic beta-Peptide Polymer (Bu:DM) Exhibiting Anti-Biofilm, Immunomodulatory, and in Vivo Anti-Infective Activity. J. Med. Chem. 2020, 63, 12921-12928.

17. Zhang, D.; Chen, Q.; Zhang, W.; Liu, H.; Wan, J.; Qian, Y.; Li, B.; Tang, S.; Liu, Y.; Chen, S.; Liu, R.* Silk‐inspired β‐peptide Materials Resist Fouling and the Foreign‐body Response. Angew. Chem. Int. Ed. 2020, 59, 9586–9593. (Hot Paper)

16. Zhou, M.; Xiao, X.; Cong, Z.; Wu, Y.; Zhang, W.; Ma, P.; Chen, S.; Zhang, H.; Zhang, D.; Zhang, D.; Luan, X.; Mai, Y.; Liu, R.* Water Insensitive Synthesis of Poly-beta-Peptides with Defined Architecture. Angew. Chem. Int. Ed. 2020,59, 7240-7244.‍

15. Zhou, M.; Qian, Y.; Xie, J.; Zhang, W.; Jiang, W.; Xiao, X.; Chen, S.; Dai, C.; Cong, Z.; Ji, Z.; Shao, N.; Liu, L.; Wu, Y.; Liu, R.* Poly(2‐Oxazoline) Based Functional Mimics of Peptides to Eradicate MRSA Infections and Persisters While Alleviating Antimicrobial Resistance. Angew. Chem. Int. Ed. 2020, 59, 6412-6419. (VIP paper, Inside Cover, Highly Cited Paper)

14. Chen, Q.; Yu, S.; Zhang, D.; Zhang, W.; Zhang, H.; Zou, J.; Mao, Z.; Yuan, Y.; Gao C.; Liu, R.* Impact of Antifouling PEG Layer on the Performance of Functional Peptides in Regulating Cell Behaviors. J. Am. Chem. Soc. 2019, 141, 16772

(Selected as the JACS supplementary cover)

(Highlighted by Sci. China Chem, 2019, DOI: 10.1007/s11426-019-9654-9)

(Highlighted by CCL, 2019, DOI: 10.1016/j.cclet.2019.10.038)

13. Wu, Y.; Zhang, D.; Ma, P.; Zhou, R.; Hua, L.; Liu, R.* Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides. Nat. Commun. 2018, 9 (1), 5297.

(Selected as the editor's choice)

(Spotlight by Acta Polymerica Sinica, 2019, 50(2): 99)

(Spotlight by J. Functional Polymers, 2019, 32(2): 120)

(Spotlight reviewed by Materials Reports, 2019, 33(1): 1)

12. Ding, X.; Duan, S.; Ding, X.; Liu, R.*; Xu, F.*, Versatile Antibacterial Materials: An Emerging Arsenal for Combatting Bacterial Pathogens. Adv. Funct. Mater. 2018, 28 (40), 19. (Highly Cited Paper)

11. Qi. F; Qian, Y.; Shao, N.; Zhou, R.; Zhang, S.; Lu Z.; Zhou, M.; Xie, J.; Wei, T.; Yu, Q.;, Liu, R.*, Practical Preparation of Infection-Resistant Biomedical Surfaces from Antimicrobial β-Peptide Polymers. ACS Appl. Mater. Interfaces 2019, 11 (21), 18907-18913.

10. Qian, Y.; Qi, F.; Chen, Q.; Zhang, Q.; Qiao, Z.; Zhang, S.; Wei, T.; Yu, Q.; Yu, S.; Mao, Z.; Gao, C.; Ding, Y.; Cheng, Y.; Jin, C.; Xie, H.; Liu, R.* Surface Modified with a Host Defense Peptide-Mimicking beta-Peptide Polymer Kills Bacteria on Contact with High Efficacy. ACS Appl. Mater. Interfaces 2018, 10 (18), 15395-15400.

9. Liu, R.; Chen, X.; Falk, S.; Masters, K. S.; Weisblum, B.; Gellman, S. H. “Nylon-3 Polymers Active against Drug-Resistant Candida albicans Biofilms” J. Am. Chem. Soc. 2015, 137: 2183-2196.

8. Liu, R.; Chen, X.; Falk, S.; Mowery, B.; Karlsson, A.; Weisblum, B.; Palecek, S.; Masters, K. S.; Gellman, S. H. “Structure–Activity Relationships among Antifungal Nylon-3 Polymers: Identification of Materials Active Against Drug-Resistant Strains of Candida albicans”, J. Am. Chem. Soc.2014, 136: 4333-4342.

(Highlighted by SciBX, SciBX 7(11), 2014, 315)

7. Liu, R.; Chen, X.; Chakraborty, S.; Lemke, J.; Hayouka, Z.; Chow, C.; Welch, R.; Weisblum, B.; Masters, K. S.; Gellman, S. H. “Tuning the Biological Activity Profile of Antibacterial Polymers via Subunit Substitution Pattern”, J. Am. Chem. Soc.2014, 136: 4410-4418.

(Highlighted by SciBX: SciBX 7(15), 2014, 441)

6. Liu, R.#; Suárez, J. M.#; Weisblum, B.; Gellman, S. H.; and McBride, S. M. “Polymers Active Against Clostridium difficile Vegetative Cell Growth and Spore Outgrowth.” J. Am. Chem. Soc. 2014, 136, 14498-14504. (equal contribution)

(Highlighted by SciBX: SciBX 7(43), 2014, 1263)

5. Chakraborty, S.#; Liu, R.#; Hayouka, Z.; Chen, X.; Ehrhardt, J.; Lu, Q.; Burke, E.; Yang, Y.; Weisblum, B.; Wong, G. C. L.; Masters, K. S; and Gellman, S. H. “Ternary nylon-3 copolymers as host-defense peptide mimics: beyond hydrophobic and cationic subunits.” J. Am. Chem. Soc.2014, 136, 14530-14535. (equal contribution)

4. Liu, R.; Chen, X.; Gellman, S. H.; Masters, K. S. “Nylon-3 Polymers that Enable Selective Culture of Endothelial Cells”, J. Am. Chem. Soc. 2013, 135: 16296-16299.

3. Liu, R.; Chen, X.; Hayouka, Z.; Chakraborty, S.; Falk, S. P.; Weisblum, B.; Masters, K. S.; Gellman, S. H. “Nylon-3 Polymers with Selective Antifungal Activity.” J Am Chem Soc. 2013, 135, 5270-5273.

(Featured in JACS Spotlights, J. Am. Chem. Soc. 2013, 135: 5933−5933)

2. Hayouka, Z.; Chakraborty, S.; Liu, R.; Boersma, M. D.; Weisblum, B.; Gellman, S. H. “Interplay among Subunit Identity, Subunit Proportion, Chain Length, and Stereochemistry in the Activity Profile of Sequence-Random Peptide Mixtures.” J. Am. Chem. Soc. 2013, 135: 11748-11751.

1. Liu, R.; Chanthamontri, C.; Han, H.; Hernández-Torres, J.M.; Wood, K.V.; Mcluckey, S.A.; Wei, A. “Solid-Phase Synthesis of α-Glucosamine Sulfoforms with Fragmentation Analysis by Tandem Mass Spectrometry.” J. Org. Chem. 2008, 73: 6059-6072.

(Featured Article)